The biological role and regulation of versican levels in cancer

Abstract

Increased expression of the proteoglycan, versican is strongly associated with poor outcome for many different cancers. Depending on the cancer type, versican is expressed by either the cancer cells themselves or by stromal cells surrounding the tumor. Versican plays diverse roles in cell adhesion, proliferation, migration and angiogenesis, all features of… (More)
DOI: 10.1007/s10555-009-9182-y

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