The biological relevance of chemokine-proteoglycan interactions.

@article{Proudfoot2006TheBR,
  title={The biological relevance of chemokine-proteoglycan interactions.},
  author={Amanda E. I. Proudfoot},
  journal={Biochemical Society transactions},
  year={2006},
  volume={34 Pt 3},
  pages={422-6}
}
Chemokines exert their biological activity through high-affinity interactions with cell-surface receptors, thereby activating specific signalling pathways, and a second low-affinity interaction with proteoglycans. Proteoglycans consist of a protein core, to which GAG (glycosaminoglycan) chains are attached. The GAGs are long, linear, sulphated and highly charged heterogeneous polysaccharides that are expressed throughout the body in different forms depending on the developmental or pathological… CONTINUE READING

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The GAGs are long , linear , sulphated and highly charged heterogeneous polysaccharides that are expressed throughout the body in different forms depending on the developmental or pathological state of the organ / organism .
The GAGs are long , linear , sulphated and highly charged heterogeneous polysaccharides that are expressed throughout the body in different forms depending on the developmental or pathological state of the organ / organism .
Proteoglycans consist of a protein core , to which GAG ( glycosaminoglycan ) chains are attached .
Proteoglycans consist of a protein core , to which GAG ( glycosaminoglycan ) chains are attached .
Proteoglycans consist of a protein core , to which GAG ( glycosaminoglycan ) chains are attached .
Proteoglycans consist of a protein core , to which GAG ( glycosaminoglycan ) chains are attached .
Proteoglycans consist of a protein core , to which GAG ( glycosaminoglycan ) chains are attached .
Proteoglycans consist of a protein core , to which GAG ( glycosaminoglycan ) chains are attached .
The GAGs are long , linear , sulphated and highly charged heterogeneous polysaccharides that are expressed throughout the body in different forms depending on the developmental or pathological state of the organ / organism .
Additionally we have shown that chemokines oligomerize on immobilized GAGs , and this ability to form higher order oligomers has also been shown to be essential for the activity of certain chemokines in vivo .
Additionally we have shown that chemokines oligomerize on immobilized GAGs , and this ability to form higher order oligomers has also been shown to be essential for the activity of certain chemokines in vivo .
Additionally we have shown that chemokines oligomerize on immobilized GAGs , and this ability to form higher order oligomers has also been shown to be essential for the activity of certain chemokines in vivo .
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