The biological paths of IL-1 family members IL-18 and IL-33.

  title={The biological paths of IL-1 family members IL-18 and IL-33.},
  author={Dirk Smith},
  journal={Journal of leukocyte biology},
  volume={89 3},
Cytokines are key mediators of the immune system, and few have been more thoroughly studied than those of the IL-1 family. IL-1α and IL-1β are the founding members and now celebrate 25 years since their cloning. In that time, IL-1-directed research has illuminated many aspects of cytokine biology and innate immunity. The family is now recognized to include 11 total members, including IL-18 and IL-33, which are the topic of this review. These two inflammatory cytokines are expressed broadly, and… CONTINUE READING

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