The biological impact of mass-spectrometry-based proteomics

@article{Cravatt2007TheBI,
  title={The biological impact of mass-spectrometry-based proteomics},
  author={B. Cravatt and G. Simon and J. Yates},
  journal={Nature},
  year={2007},
  volume={450},
  pages={991-1000}
}
In the past decade, there have been remarkable advances in proteomic technologies. Mass spectrometry has emerged as the preferred method for in-depth characterization of the protein components of biological systems. Using mass spectrometry, key insights into the composition, regulation and function of molecular complexes and pathways have been gained. From these studies, it is clear that mass-spectrometry-based proteomics is now a powerful 'hypothesis-generating engine' that, when combined with… Expand
607 Citations

Figures and Topics from this paper

Mass spectrometry–based proteomics in cell biology
  • 408
  • PDF
Mass Spectrometry-Based Approaches Toward Absolute Quantitative Proteomics
  • 83
  • PDF
Advances in quantitative proteomics
  • 8
ICP-MS-based strategies for protein quantification.
  • 83
Quantitative protein analysis by mass spectrometry.
  • 22
Mass Spectrometry-Based Biomarker Discovery.
  • 9
Elective affinities – Bioinformatic analysis of proteomic mass spectrometry data
  • 10
Mass-spectrometric exploration of proteome structure and function
  • 810
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 78 REFERENCES
Mass spectrometry-based proteomics
  • 5,888
  • PDF
Mass Spectrometry and Protein Analysis
  • 1,704
  • PDF
Mass spectral analysis in proteomics.
  • J. Yates
  • Chemistry, Medicine
  • Annual review of biophysics and biomolecular structure
  • 2004
  • 286
Protein microarrays and proteomics
  • 762
  • PDF
The development and application of methods for activity-based protein profiling.
  • 176
  • PDF
Disease proteomics : Proteomics
  • 535
Disease proteomics
  • 422
  • PDF
...
1
2
3
4
5
...