The biological hallmarks of ileal carcinoids

@article{Cunningham2011TheBH,
  title={The biological hallmarks of ileal carcinoids},
  author={Janet L. Cunningham and Eva Tiensuu Janson},
  journal={European Journal of Clinical Investigation},
  year={2011},
  volume={41}
}
Eur J Clin Invest 2011; 41 (12): 1353–1360 
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Polyclonal Crypt Genesis and Development of Familial Small Intestinal Neuroendocrine Tumors.
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Characterization of early tumor formation of SI-NET, observed as crypt-based EC cell clusters in many cases of familial SI- NETs, suggests that the +4 active reserve EC cell subset is the cell of origin.
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Experiments in Drosophila indicate that Ret is expressed both by enteric neurons and adult intestinal epithelial progenitors, which require Ret to sustain their proliferation, and suggest an epithelial contribution to Ret loss‐of‐function disorders such as Hirschsprung disease.
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The aim of this study was to identify the miRNA profile of well-differentiated small intestinal neuroendocrine tumors, which may have a critical role in tumor development, progression and potentially develop miRNAs as novel clinical biomarkers.

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