The biological function of insulin-like growth factor-I in myogenesis and its therapeutic effect on muscular dystrophy.

  • Satoru Noguchi
  • Published 2005 in
    Acta myologica : myopathies and cardiomyopathies…


In progressive muscular dystrophy, such as Duchenne muscular dystrophy, muscles show the pathological changes characterized by hypertrophy at the early phase, while atrophic changes are seen with aging. As an experimental model for muscle hypertrophy and atrophy, insulin-like growth factor-1 (IGF-1) signaling via the activation of PI3K/Akt pathway has been… (More)