The biological function of antibodies induced by the RTS,S/AS01 malaria vaccine candidate is determined by their fine specificity

@inproceedings{Chaudhury2016TheBF,
  title={The biological function of antibodies induced by the RTS,S/AS01 malaria vaccine candidate is determined by their fine specificity},
  author={Sidhartha Chaudhury and Christian F. Ockenhouse and Jason A. Regules and Sheetij Dutta and Anders Wallqvist and Erik Jongert and Norman C. Waters and Franck Lemiale and Elke S Bergmann-Leitner},
  booktitle={Malaria Journal},
  year={2016}
}
BackgroundRecent vaccine studies have shown that the magnitude of an antibody response is often insufficient to explain efficacy, suggesting that characteristics regarding the quality of the antibody response, such as its fine specificity and functional activity, may play a major role in protection. Previous studies of the lead malaria vaccine candidate, RTS,S, have shown that circumsporozoite protein (CSP)-specific antibodies and CD4+ T cell responses are associated with protection, however… CONTINUE READING
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