The biological chemistry of folate receptors.

  title={The biological chemistry of folate receptors.},
  author={Aśok C. Antony},
  volume={79 11},
HE ESSENTIAL role of intracellular folates in ef-T fecting one-carbon transfers in critical enzyme systems for DNA synthesis is well This has led to extensive application of various synthetic folate analogues as therapeutic and investigative tools in a variety of infectious, immunologic, and neoplastic diseases, as well as in developmental, transplantation, and tumor b i o l ~ g y. ~ , ~ While the enzyme dihydrofolate reductase (DHFR), the major target for the antifolate, methotrexate (MTX), is… CONTINUE READING
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Evidence that the hydrophobicity of isolated , in situ , and de novosynthesized placental folate receptors is a function of glycosylphosphatidylinositol anchoring to membranes

  • RF Branda, BK Anthony, HS Jacob
  • J Biol Chem
  • 1992

Sequestration and transport of small moelcules by caveolae

  • Anderson RGW, BA Kamen, KG Rothberg, Lacey SW Potocytosis
  • Science
  • 1992

Charac - terization of two cDNAs encoding folatebinding proteins from L 1210 murine leukemia cells . Increased expression associated with a genomic rearrangement

  • LR Coney, A Tomassetti, +4 authors VR Zurawski
  • J Biol Chem
  • 1991

Cloning of tumorassociated antigen : MOv 18 and MOv 19 antibodies recognize a folatebinding protein

  • AC Antony, RS Verma
  • Cancer Res
  • 1991

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