The biological buffer bicarbonate/CO2 potentiates H2O2-mediated inactivation of protein tyrosine phosphatases.

@article{Zhou2011TheBB,
  title={The biological buffer bicarbonate/CO2 potentiates H2O2-mediated inactivation of protein tyrosine phosphatases.},
  author={Haiying Zhou and Harkewal Singh and Zachary D. Parsons and Sarah M. Lewis and Sanjib Bhattacharya and Derrick R. Seiner and Jason N. Labutti and Thomas Joseph Reilly and John J. Tanner and Kent S Gates},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 40},
  pages={
          15803-5
        }
}
Hydrogen peroxide is a cell signaling agent that inactivates protein tyrosine phosphatases (PTPs) via oxidation of their catalytic cysteine residue. PTPs are inactivated rapidly during H(2)O(2)-mediated cellular signal transduction processes, but, paradoxically, hydrogen peroxide is a rather sluggish PTP inactivator in vitro. Here we present evidence that the biological buffer bicarbonate/CO(2) potentiates the ability of H(2)O(2) to inactivate PTPs. The results of biochemical experiments and… CONTINUE READING
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