The biological and clinical impact of inhibition of NF-κB-initiated apoptosis in diffuse large B cell lymphoma (DLBCL).

@article{Bavi2011TheBA,
  title={The biological and clinical impact of inhibition of NF-κB-initiated apoptosis in diffuse large B cell lymphoma (DLBCL).},
  author={Prashant Bavi and Shahab Uddin and Rong Bu and Maqbool Ahmed and Jehad Abubaker and Valorie Balde and Zeeshan Qadri and Dahish S. Ajarim and Fouad Hassan Al-Dayel and Azhar R. Hussain and Khawla S Al-Kuraya},
  journal={The Journal of pathology},
  year={2011},
  volume={224 3},
  pages={355-66}
}
NF-κB is frequently over-expressed in a variety of non-Hodgkin's lymphomas (NHLs) and has been implicated in lymphomagenesis; however, its role in diffuse large B cell lymphoma (DLBCL) as a prognostic biomarker has not been fully elucidated. Therefore, we investigated the role of NF-κB and its association with clinicopathological features in a tissue microarray cohort of 230 DLBCL patient samples. We then elucidated the role of NF-κB inhibition on cell viability and apoptosis in vitro, using… CONTINUE READING