The biological activity of hydrogen peroxide. I. Induction of chromosome-type aberrations susceptible to inhibition by scavengers of hydroxyl radicals in human embryonic fibroblasts.

@article{Oya1986TheBA,
  title={The biological activity of hydrogen peroxide. I. Induction of chromosome-type aberrations susceptible to inhibition by scavengers of hydroxyl radicals in human embryonic fibroblasts.},
  author={Y. Oya and K. Yamamoto and A. Tonomura},
  journal={Mutation research},
  year={1986},
  volume={172 3},
  pages={
          245-53
        }
}
  • Y. Oya, K. Yamamoto, A. Tonomura
  • Published 1986
  • Biology, Medicine
  • Mutation research
  • The cytogenetic effect of hydrogen peroxide (H2O2) was investigated in human embryonic fibroblasts. Chromosome-type aberrations were found together with chromatid-type aberrations in metaphase cells harvested 24 h after a single 10-min treatment with 10(-5)-10(-3) M H2O2 in 0.9% NaCl solution. The chromosome-type aberrations were observed to be predominantly dicentrics and deletions. Both types of aberration showed a dose-response relationship to the dose of H2O2 over the range of 10(-5)-1.5 X… CONTINUE READING

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