The biological activity of auranofin: implications for novel treatment of diseases

@article{Madeira2012TheBA,
  title={The biological activity of auranofin: implications for novel treatment of diseases},
  author={Jocelyn M. Madeira and David S. Gibson and Walter F. Kean and Andis Klegeris},
  journal={Inflammopharmacology},
  year={2012},
  volume={20},
  pages={297-306}
}
More than 30 years ago, auranofin was developed for the treatment of rheumatoid arthritis as a substitution for the injectable gold compounds aurothiomalate and aurothioglucose. Both the ease of oral administration over intramuscular injections and more potent anti-inflammatory effects in vitro made auranofin seem like an excellent substitute for the traditional injectable gold compounds. Despite efficacy in the treatment of both rheumatoid arthritis and psoriasis, currently, auranofin is… CONTINUE READING