The biological activity of 3α-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury

@article{Meyer2008TheBA,
  title={The biological activity of 3$\alpha$-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury},
  author={L. Meyer and C. Venard and V. Schaeffer and C. Patte-Mensah and A. Mensah-Nyagan},
  journal={Neurobiology of Disease},
  year={2008},
  volume={30},
  pages={30-41}
}
Identification of cellular targets pertinent for the development of effective therapies against pathological pain constitutes a difficult challenge. We combined several approaches to show that 3alpha-hydroxysteroid oxido-reductase (3alpha-HSOR), abundantly expressed in the spinal cord (SC), is a key target, the modulation of which markedly affects nociception. 3alpha-HSOR catalyzes the biosynthesis and oxidation of 3alpha,5alpha-reduced neurosteroids as allopregnanolone (3alpha,5alpha-THP… Expand
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