The biologic role of interleukin-8: functional analysis and expression of CXCR1 and CXCR2 on human eosinophils.

@article{Petering1999TheBR,
  title={The biologic role of interleukin-8: functional analysis and expression of CXCR1 and CXCR2 on human eosinophils.},
  author={Holger Petering and Otto Goetze and Daniela Kimmig and Regina Smolarski and Alexander Kapp and J{\"o}rn Elsner},
  journal={Blood},
  year={1999},
  volume={93 2},
  pages={694-702}
}
Chemokines play an important role in attracting granulocytes into sites of inflammation. Two chemokine subfamilies differ in their biologic activity for different granulocyte subsets. Whereas CXC chemokines such as interleukin-8 (IL-8) activate predominantly neutrophils, CC chemokines such as RANTES and eotaxin activate predominantly eosinophils. However, controversial results have been published in the past regarding the biologic role of IL-8 in eosinophil activation, particularly in allergic… CONTINUE READING
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