The biogenesis of the Golgi ribbon: the roles of membrane input from the ER and of GM130.

@article{Marra2007TheBO,
  title={The biogenesis of the Golgi ribbon: the roles of membrane input from the ER and of GM130.},
  author={Pierfrancesco Marra and Lorena Salvatore and Alexander E. Mironov and Antonella Di Campli and Giuseppe Di Tullio and Alvar Trucco and Galina V. Beznoussenko and Maria Antonietta De Matteis},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 5},
  pages={
          1595-608
        }
}
The Golgi complex in mammalian cells forms a continuous ribbon of interconnected stacks of flat cisternae. We show here that this distinctive architecture reflects and requires the continuous input of membranes from the endoplasmic reticulum (ER), in the form of pleiomorphic ER-to-Golgi carriers (EGCs). An important step in the biogenesis of the Golgi ribbon is the complete incorporation of the EGCs into the stacks. This requires the Golgi-matrix protein GM130, which continuously cycles between… CONTINUE READING

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