The biogenesis of platelets from megakaryocyte proplatelets.

  title={The biogenesis of platelets from megakaryocyte proplatelets.},
  author={Sunita R. Patel and John H. Hartwig and Joseph E. Italiano},
  journal={The Journal of clinical investigation},
  volume={115 12},
Platelets are formed and released into the bloodstream by precursor cells called megakaryocytes that reside within the bone marrow. The production of platelets by megakaryocytes requires an intricate series of remodeling events that result in the release of thousands of platelets from a single megakaryocyte. Abnormalities in this process can result in clinically significant disorders. Thrombocytopenia (platelet counts less than 150,000/microl) can lead to inadequate clot formation and increased… CONTINUE READING
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  • The Journal of Clinical Investigation
  • 2005

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