The biodistribution of 5-[18F]fluoropyrazinamide in Mycobacterium tuberculosis-infected mice determined by positron emission tomography

Abstract

5-[18F]F-pyrazinamide (5-[18F]F-PZA), a radiotracer analog of the first-line tuberculosis drug pyrazinamide (PZA), was employed to determine the biodistribution of PZA using PET imaging and ex vivo analysis. 5-[18F]F-PZA was synthesized in 60 min using a halide exchange reaction. The overall decay-corrected yield of the reaction was 25% and average specific… (More)
DOI: 10.1371/journal.pone.0170871

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@inproceedings{Zhang2017TheBO, title={The biodistribution of 5-[18F]fluoropyrazinamide in Mycobacterium tuberculosis-infected mice determined by positron emission tomography}, author={Zhuo Zhang and Alvaro A. Ordonez and Peter M. Smith-Jones and Hui Wang and Kayla R. Gogarty and Fereidoon Daryaee and Lauren E Bambarger and Yong Sheng Chang and Sanjay K. Jain and Peter J. Tonge}, booktitle={PloS one}, year={2017} }