The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides.

@article{Gao2011TheBA,
  title={The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides.},
  author={Guangzheng Gao and Dirk Lange and Kai Hilpert and Jason Kindrachuk and Yuquan Zou and John T-J Cheng and Mehdi Kazemzadeh-Narbat and Kai Yu and Rizhi Wang and Suzana K. Straus and Donald Elliott Brooks and Ben H. Chew and Robert E. Hancock and Jayachandran N Kizhakkedathu},
  journal={Biomaterials},
  year={2011},
  volume={32 16},
  pages={3899-909}
}
Bacterial colonization on implant surfaces and subsequent infections are one of the most common reasons for the failure of many indwelling devices. Several approaches including antimicrobial and antibiotic-eluting coatings on implants have been attempted; however, none of these approaches succeed in vivo. Here we report a polymer brush based implant coating that is non-toxic, antimicrobial and biofilm resistant. These coating consists of covalently grafted hydrophilic polymer chains conjugated… CONTINUE READING

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