The biochemistry of memory: a new and specific hypothesis.

@article{Lynch1984TheBO,
  title={The biochemistry of memory: a new and specific hypothesis.},
  author={Gary Lynch and Michel Baudry},
  journal={Science},
  year={1984},
  volume={224 4653},
  pages={
          1057-63
        }
}
Recent studies have uncovered a synaptic process with properties required for an intermediate step in memory storage. Calcium rapidly and irreversibly increases the number of receptors for glutamate (a probable neurotransmitter) in forebrain synaptic membranes by activating a proteinase (calpain) that degrades fodrin, a spectrin-like protein. This process provides a means through which physiological activity could produce long-lasting changes in synaptic chemistry and ultrastructure. Since the… 
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References

SHOWING 1-10 OF 59 REFERENCES
Molecular biology of learning: modulation of transmitter release.
TLDR
This review focuses primarily on short-term sensitization of the gill and siphon reflex in the marine mollusk, Aplysia californica, and analyses of this form of learning provide direct evidence that protein phosphorylation dependent on cyclic adenosine monophosphate can modulate synaptic action.
Do dendritic spines twitch?
  • F. Crick
  • Biology
    Trends in Neurosciences
  • 1982
Classification and properties of acidic amino acid receptors in hippocampus. II. Biochemical studies using a sodium efflux assay.
TLDR
The similarities in the properties of excitatory amino acid receptors evidenced with the 22Na efflux assay or with the electrophysiological approach in the in vitro hippocampal slice preparation indicate that the same receptors are sampled by the two techniques.
Regulation of hippocampal glutamate receptors: evidence for the involvement of a calcium-activated protease.
  • M. BaudryG. Lynch
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1980
TLDR
It is suggested that an endogenous membrane-associated thiol protease regulates the number of [3H]glutamate binding sites in hippocampal membranes and that this is the mechanism by which calcium stimulates glutamate binding.
Identification of pyramidal cells as the critical elements in hippocampal neuronal plasticity during learning.
  • T. BergerR. Thompson
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1978
TLDR
The major output neurons of the hippocampus appear to be the neuroanatomical substrate for the large and rapidly developing neuronal plasticity induced by this classical conditioning paradigm.
Intracellular injections of EGTA block induction of hippocampal long-term potentiation
TLDR
It is reported that intracellular injections of the calcium chelator EGTA block the development of LTP and this results strongly suggest that LTP is caused by a modification of the postsynaptic neurone and that its induction depends on the level of free calcium.
Associative long-term potentiation in hippocampal slices.
TLDR
This form of long-term synaptic potentiation (LTP), known as associative LTP, was shown in some cases to last hours without decrement and could not be accounted for by any of several measured postsynaptic passive membrane properties.
...
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