The biochemical modes of action of vitamin e and selenium: A hypothesis

@article{Diplock1973TheBM,
  title={The biochemical modes of action of vitamin e and selenium: A hypothesis},
  author={A. T. Diplock and Jack A. Lucy},
  journal={FEBS Letters},
  year={1973},
  volume={29}
}
The role of vitamin E in biological membranes.
  • A. Diplock
  • Biology, Chemistry
    Ciba Foundation symposium
  • 1983
TLDR
The results suggest that alpha-tocopherol is capable of exerting a controlling influence upon the linoleyl and arachidonyl residues within membrane phospholipids which cannot be explained on the basis of the antioxidant function of the vitamin, and which may provide evidence for the above hypothesis.
Possible stabilizing effect of vitamin E on microsomal, membrane-bound, selenide-containing proteins and drug-metabolizing enzyme systems
TLDR
It will be shown that the inductive effect of phenobarbitone on the microsomal drug-metabolizing enzyme system of normal rats is accompanied by a large increase in the uptake of selenium and its conversion to selenide; when vitamin E is withdrawn from the diet, this effect cannot be demonstrated.
DEVELOPMENT OF GLUTATHIONE PEROXIDASE ACTIVITY IN MUSCLE AND LIVER OF NORMAL AND VITAMIN E‐DEFICIENT DUCKLINGS IN RELATION TO DIETARY SELENIUM CONTENT
TLDR
The development of GSH peroxidase activity from shortly before hatching until 10 weeks after hatching is reported in skeletal muscle and liver of normal and E-deficient ducklings in relation to dietary selenium content.
Metabolic aspects of selenium action and toxicity.
The nutritional observations, on which the activity of selenium is based, are briefly reviewed, and the interactions of the trace element with vitamin E, polyunsaturated fatty acids, and sulfur amino
Metabolic and functional defects in selenium deficiency
TLDR
The conclusion is reached that the blood selenium level of populations in Keshan disease regions are exceptionally low and that Keshans disease is the first demonstration that selenum is an essential trace element for man.
Vitamin E as an antioxidant in vitro and in vivo.
TLDR
Vitamin E and total lipid-soluble, chain-breaking antioxidant concentrations in some normal and cancerous tissues have been measured and a number of unresolved problems relating to the action of vitamin E in vivo are discussed.
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Vitamin E and stress
TLDR
A critical analysis of the biological antioxidant theory of vitamin E function has been made and the implications of the theory have been tested and it was found that the importance of oxidative destruction of tocopherol in the gut before absorption was demonstrated.
The effect of vitamin E on the intracellular distribution of the different oxidation states of selenium in rat liver.
TLDR
The hypothesis that the active form of selenium may be selenides located in non-haem iron-containing proteins, and that the function of vitamin E may be to protect the selenide from oxidation is supported.
Measurements of lipid peroxidation and α-tocopherol destruction in vitro and in vivo and their significance in connexion with the biological function of vitamin E
TLDR
Investigation of the relationship between fatty acid peroxidation and a-tocopherol in vitro finds that the greater the degree of unsaturation of the substrate, the greater was the amount of tocopherol destroyed at any given time before the end of the induction period.
The effect of vitamin E on the oxidation state of selenium in rat liver.
TLDR
The results are consistent with the hypothesis that the active form of Se may be Se and that the selenide may form part of the active centre of an uncharacterized class of catalytically active non-haem-iron proteins that are protected from oxidation in vivo by vitamin E.
Identification of a phospholipase A1 in plasma membranes of rat liver.
The influence of vitamin E deficiency on biological membranes. An ultrastructural study on the intestinal epithelial cells of ducklings.
The influence of vitamin E deficiency on the ultrastructure of intestinal epithelial cells and their membranes in particular was studied in groups of ducklings receiving vitamin E deficient and contro
Relation of mitochondrial phospholipase A activity to mitochondrial swelling.
TLDR
The temperature dependence of spontaneous, fatty acid-induced, or CaCl(2)-induced swelling suggested that enzymatic activities are responsible for swelling, although swelling due to contaminating lysosomes cannot be excluded entirely.
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