The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance.


IMPORTANCE OF THE FIELD Disrupted l-methionine (Met) metabolism can lead to hepatic, neurological and cardiovascular dysfunction in humans. Aberrant methyl group flux likely contributes to the development of these pathologies, but when patients also become hypermethionemic, additional toxicological mechanisms may be relevant. AREAS COVERED IN THIS REVIEW… (More)
DOI: 10.1517/17425255.2010.522177