The biochemical and pharmacological activity of 9-benzyl-9-deazaguanine, a potent purine nucleoside phosphorylase (PNP) inhibitor

@article{Kimble2005TheBA,
  title={The biochemical and pharmacological activity of 9-benzyl-9-deazaguanine, a potent purine nucleoside phosphorylase (PNP) inhibitor},
  author={E. Kimble and J. Hadala and R. Ludewig and P. Peters and G. Greenberg and G. Xiao and W. Guida and L. Mcquire and P. {\vS}imon},
  journal={Inflammation Research},
  year={2005},
  volume={44},
  pages={S181-S182}
}
Patients deficient in purine nucleoside phosphorylase (PNP), show marked impairment in T-cell immune function but normal to elevated B-cell function [1], The mechanism for this deficiency involves a build-up of increased levels of deoxyguanosine leading to the synthesis of high amounts of deoxyguanosine triphosphate (dGTP) in T-cells [2]. dGTP inhibits the reduction of ribonucleotides to deoxyribonucleotides, impairing D N A synthesis and thereby selectively reducing T-cell proliferation [3… Expand
1 Citations

References

SHOWING 1-8 OF 8 REFERENCES
Purine Nucleoside Phosphorylase
Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).
An enzymic method for the determination of inorganic phosphate in serum.
Purine nucleoside phosphorylase ( PNP ) inhibitors : potentially selective immunosuppressive agents
  • Drugs Future
  • 1988