The bioactivity of saponins: triterpenoid and steroidal glycosides.


Triterpenoid and steroidal glycosides, referred to collectively as saponins, are bioactive compounds present naturally in many plants. They have considerable potential as pharmaceutical and/or nutraceutical agents in natural or synthetic form. Saponins, from a variety of sources, have been shown to have hypocholesterolemic, anti-coagulant, anticarcinogenic, hepatoprotective, hypoglycemic, immunomodulatory, neuroprotective, anti-inflammatory and anti-oxidant activity. This paper reviews saponin research of the last decade, focussing on developments in understanding their mechanism of action and structure-activity relationships. Virtually all of this work has used animal and in vitro models. To date there are very few human data.

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@article{Rao2000TheBO, title={The bioactivity of saponins: triterpenoid and steroidal glycosides.}, author={A. Venketeshwer Rao and Debbie M. Gurfinkel}, journal={Drug metabolism and drug interactions}, year={2000}, volume={17 1-4}, pages={211-35} }