The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters.

@article{Geissler2010TheBD,
  title={The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters.},
  author={Stefanie Geissler and Madlen Zwarg and Ilka Kn{\"u}tter and Fritz Markwardt and Matthias Brandsch},
  journal={The FEBS journal},
  year={2010},
  volume={277 3},
  pages={790-5}
}
The bioactive dipeptide derivative anserine (beta-alanyl-1-N-methyl-L-histidine) is absorbed from the human diet in intact form at the intestinal epithelium. The purpose of this study was to investigate whether anserine is a substrate of the H(+)/peptide cotransporters 1 and 2 (PEPT1 and PEPT2). We first assessed the effects of anserine on [(14)C]glycylsarcosine ([(14)C]Gly-Sar) uptake into Caco-2 cells expressing human PEPT1 and into spontaneous hypertensive rat kidney proximal tubule (SKPT… CONTINUE READING
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