The binding site on SV40 DNA for a T antigen-related protein.

  title={The binding site on SV40 DNA for a T antigen-related protein.},
  author={Robert Tjian},
  volume={13 1},
A protein closely related to SV40 T antigen was purified in a biologically active form from cells infected with the defective adenovirus-SV40 hybrid, Ad2+D2. This 107,000 dalton hybrid protein binds and protects a specific portion of SV40 DNA from digestion by pancreatic DNAase I. Hybridization, endonuclease cleavage and pyrimidine tract analysis of the protected fragments reveal that the D2 hybrid protein binds in a sequential manner to tandem recognition sites which lie within a sequence of… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 8 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.
54 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 54 extracted citations

Similar Papers

Loading similar papers…