The binding properties of two antitumor ruthenium(III) complexes to apotransferrin.

@article{Kratz1994TheBP,
  title={The binding properties of two antitumor ruthenium(III) complexes to apotransferrin.},
  author={Felix Kratz and M. A. Hartmann and Bernhard Keppler and Luigi Messori},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 4},
  pages={2581-8}
}
The interaction of two ruthenium(III) complexes exhibiting high anticancer activity, namely trans-indazolium(bisindazole)tetrachlororuthenate(III) (ru-ind) and trans-imidazolium(bisimidazole)tetrachlororuthenate(III) (ru-im), with human serum apotransferrin has been investigated through spectroscopic and chromatographic techniques with the ultimate goal of preparing adducts with good selectivity for cancer cells. Whereas the binding of ru-im to human serum apotransferrin takes several hours, ru… CONTINUE READING