The binding of thio-TEPA in human serum and to isolated serum protein fractions

Abstract

Binding of triethylenethiophosphoramide (thio-TEPA) in serum from healthy individuals and from cancer patients and its binding to isolated serum protein fractions were studied by equilibrium dialysis. A drug-protein binding in the order of 10% was demonstrated in serum, with little interindividual variation. The protein binding of thio-TEPA seemed to be restricted to albumin and lipoproteins, with the greatest affinity to albumin. The previously reported selective binding of thio-TEPA to gamma globulin was contrary to our findings. The almost insignificant degree of serum protein binding of thio-TEPA indicates that the drug is well suited for use in cancer drug combinations.

DOI: 10.1007/BF00262584

2 Figures and Tables

Statistics

010002000'92'95'98'01'04'07'10'13'16
Citations per Year

245 Citations

Semantic Scholar estimates that this publication has 245 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Hagen1987TheBO, title={The binding of thio-TEPA in human serum and to isolated serum protein fractions}, author={Bj\orn Hagen and Odd Georg Nilsen}, journal={Cancer Chemotherapy and Pharmacology}, year={1987}, volume={20}, pages={319-323} }