The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of beta-like globin genes.

@article{Feng2005TheBO,
  title={The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of beta-like globin genes.},
  author={Dongxiao Feng and Yuet Wai Kan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 28},
  pages={9896-900}
}
To investigate the function of transcription factor Sp1 in beta-like globin gene activation, we analyzed the recruitment of Sp1, fetal Krüppel-like factor 2 (FKLF2), and related factors at the human beta-globin locus in a human fetal liver and mouse erythroleukemia hybrid cell (A181gamma cell) that contains a single copy of human chromosome 11. Sp1 binds at the GT boxes of the cis-elements throughout the beta-locus, but it is phosphorylated and lost over DNase I hypersensitive site (HS)2, HS3… CONTINUE READING

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