The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper.

@article{Wilkins2010TheBO,
  title={The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper.},
  author={Simon G. Wilkins and Ashraf A Choglay and J. Paul Chapple and J van der Spuy and Alexandre G O Rhie and Christopher R. Birkett and Michael E Cheetham},
  journal={The international journal of biochemistry & cell biology},
  year={2010},
  volume={42 7},
  pages={
          1226-32
        }
}
Conformational transitions in the prion protein (PrP) are thought to be central to the pathogenesis of the transmissible spongiform encephalopathies (TSE), such as Creutzfeldt-Jacob disease and bovine spongiform encephalopathy. Studies of prion phenomena in yeast have shown that molecular chaperones play an important role in prion related conformational transitions. Here, we investigated the interaction of the molecular chaperone Hsc70 (HSPA8) with recombinant PrP in vitro using an ELISA based… CONTINUE READING

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References

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SHOWING 1-10 OF 37 REFERENCES

Converging concepts of protein folding in vitro and in vivo

S ornemann, R Glockshuber
  • Nat Struct Mol Biol
  • 2009

Identification of an intracellular site of prion conversion

SL Newmyer, SL Schmid
  • PLoS Pathog
  • 2009

Hsp 104 , Hsp 70 and Hsp 40 interplay regulates formation , growth and elimination of Sup 35 prions

J Stockel, J Safar, AC Wallace, FE Cohen, SB Prusiner
  • Embo J
  • 2008

Molecular chaperones and photoreceptor function

C rammer, I Vorberg, HM Schatzl, S Gilch
  • Prog Retin Eye Res
  • 2008

Chaperone - mediated

DG onne, JH Viles, +3 authors FE Cohen
  • autophagy
  • 2007

Multiple roles of auxilin and hsc 70 in clathrin - mediated endocytosis

P ernandez-Funez, S Casas-Tinto, +3 authors AC Cepeda-Nieto
  • Traffic
  • 2007