The binding of aryl carboxylic acid derivatives to human serum albumin--a structure-activity study.

Abstract

The binding interactions of some aryl carboxylic acid derivatives have been examined by circular dichroism and fluorescence spectroscopy. With specific probes, we have shown that the seven ligands under study bind primarily to the benzodiazepine site on HSA. Their association constants are in the range of 10(5)-10(6) M-1 as found by spectropolarimetric… (More)

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Cite this paper

@article{Urien1984TheBO, title={The binding of aryl carboxylic acid derivatives to human serum albumin--a structure-activity study.}, author={Sa{\"i}k Urien and Philippe D'Athis and J. P. Tillement}, journal={Biochemical pharmacology}, year={1984}, volume={33 14}, pages={2283-9} }