The binding of CCL2 to the surface of Trypanosoma cruzi induces chemo-attraction and morphogenesis.

@article{Yamauchi2007TheBO,
  title={The binding of CCL2 to the surface of Trypanosoma cruzi induces chemo-attraction and morphogenesis.},
  author={Lucy Megumi Yamauchi and J{\'u}lio C. S. Aliberti and Marcelo Dias Baruffi and Ricardo W Portela and Marcos Ant{\^o}nio Rossi and Ricardo Tostes Gazzinelli and Jos{\'e} Roberto Mineo and Jo{\~a}o S. Silva},
  journal={Microbes and infection},
  year={2007},
  volume={9 1},
  pages={111-8}
}
Adhesion of Trypanosoma cruzi to host cells employs mechanisms which are complex and not completely understood. Upon infection, host cells release pro-inflammatory cytokines and chemokines in the environment. These had been found to be involved with increasing parasite uptake as well as killing by macrophages and cardiomyocytes. In the present study, we focused on the interaction of murine beta-chemokine CCL2 with trypomastigote forms of T. cruzi. We found that this chemokine directly triggers… CONTINUE READING