The binding of BmK abT, a unique neurotoxin, to mammal brain and insect Na(+) channels using biosensor.

@article{Ji2002TheBO,
  title={The binding of BmK abT, a unique neurotoxin, to mammal brain and insect Na(+) channels using biosensor.},
  author={Y H Ji and Wei-xi Wang and Qiong Wang and Yong-Ping Huang},
  journal={European journal of pharmacology},
  year={2002},
  volume={454 1},
  pages={25-30}
}
The binding properties of BmK abT (a novel neurotoxic polypeptide abT from Chinese scorpion Buthus martensi Karsch), a unique neurotoxin from Chinese scorpion, on mammal brain and insect sodium channels were investigated using the BIAcore assay. Results showed that BmK abT could bind to rat brain synaptosomes with an association rate constant of about 2.49 x 10(6) M(-1) s(-1) and a dissociation rate constant of about 1.57 x 10(-4) s(-1), and to Heliothis nerve cord synaptosomes with an… CONTINUE READING
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