The binding of 3H-quinuclidinyl benzilate to cholinergic muscarinic receptors in rat brain region following chronic treatment with morphine and during abstinence.


Chronic morphine treatment (subcutaneous pellet implantation of four morphine pellets) caused significant tolerance to morphine analgesia as observed at zero and 6 hrs. after pellet removal. However, such treatment failed to elicit any changes in striatal muscarinic receptors using (3H)-QNB binding studies. At 24 hours after pellet removal there was… (More)


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