The binding interactions of Ro 40-5967 at the L-type Ca2+ channel in cardiac tissue.

@article{Rutledge1995TheBI,
  title={The binding interactions of Ro 40-5967 at the L-type Ca2+ channel in cardiac tissue.},
  author={A. Rutledge and David J. Triggle},
  journal={European journal of pharmacology},
  year={1995},
  volume={280 2},
  pages={155-8}
}
Ro 40-5967 [(1S,2S)-2-[2[3-(2-benzamidopropyl]- methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl- methoxyacetate] is a new Ca2+ channel antagonist active at L-type channels. Radioligand binding studies in cardiac tissue show that Ro 40-5967 does not inhibit 1,4-dihydropyridine binding, but does inhibit diltiazem, desmethoxyverapamil and SR 33557 binding with IC50 values of 8 x 10(-9), 10(-8) and 5 x 10(-8) M, respectively. Equilibrium and kinetic binding studies showed that… CONTINUE READING

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