The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin.

@article{Urfer1994TheBE,
  title={The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin.},
  author={Roman Urfer and Pantelis Tsoulfas and Dan Soppet and Enrique Escand{\'o}n and Luis F Parada and Leonard G. Presta},
  journal={The EMBO journal},
  year={1994},
  volume={13 24},
  pages={
          5896-909
        }
}
Survival and maintenance of vertebrate neurons are influenced by neurotrophic factors which mediate their signal by binding to specific cell surface receptors. We determined the binding sites of human neurotrophin-3 (NT-3) to its receptors trkC and gp75 by mutational analysis and compared them to the analogous interactions of nerve growth factor (NGF) with trkA and gp75. The trkC binding site extends around the central beta-strand bundle and in contrast to NGF does not make use of non-conserved… CONTINUE READING
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