The binding avidity of a nanoparticle-based multivalent targeted drug delivery platform.

@article{Hong2007TheBA,
  title={The binding avidity of a nanoparticle-based multivalent targeted drug delivery platform.},
  author={Seungpyo Hong and Pascale R. Leroueil and Istv{\'a}n J Majoros and Bradford G. Orr and James R Baker and Mark M Banaszak Holl},
  journal={Chemistry & biology},
  year={2007},
  volume={14 1},
  pages={107-15}
}
Dendrimer-based anticancer nanotherapeutics containing approximately 5 folate molecules have shown in vitro and in vivo efficacy in cancer cell targeting. Multivalent interactions have been inferred from observed targeting efficacy, but have not been experimentally proven. This study provides quantitative and systematic evidence for multivalent interactions between these nanodevices and folate-binding protein (FBP). A series of the nanodevices were synthesized by conjugation with different… CONTINUE READING