The binding ability of insulin-related peptides as the clue to the search for their functional role in phylogenesis. Introduction to the problem

@article{Kolychev2008TheBA,
  title={The binding ability of insulin-related peptides as the clue to the search for their functional role in phylogenesis. Introduction to the problem},
  author={Alexander P. Kolychev},
  journal={Journal of Evolutionary Biochemistry and Physiology},
  year={2008},
  volume={44},
  pages={766-785}
}
The common plan of structure of the main peptides of the vertebrate insulin family—insulin itself, IGF-I, IGF-II, and relaxin—has distinct structural formations. Each of the peptides performs its characteristic function. However, overlapping of insulin and IGF-I actions and its stability in the vertebrate phylogenesis have formed the concept of their regulation of growth and metabolism as a function fixed in phylogenesis for a certain type of structures. At the same time, study of insulin… CONTINUE READING

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