The bimodal role of filamin in controlling the architecture and mechanics of F-actin networks.

@article{Tseng2004TheBR,
  title={The bimodal role of filamin in controlling the architecture and mechanics of F-actin networks.},
  author={Yiider Tseng and Kwang M An and Osigwe Esue and Denis Wirtz},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 3},
  pages={1819-26}
}
Reconstituted actin filament networks have been used extensively to understand the mechanics of the actin cortex and decipher the role of actin cross-linking proteins in the maintenance and deformation of cell shape. However, studies of the mechanical role of the F-actin cross-linking protein filamin have led to seemingly contradictory conclusions, in part due to the use of ill-defined mechanical assays. Using quantitative rheological methods that avoid the pitfalls of previous studies, we… CONTINUE READING