The biliverdin-bilirubin antioxidant cycle of cellular protection: Missing a wheel?

@article{Mcdonagh2010TheBA,
  title={The biliverdin-bilirubin antioxidant cycle of cellular protection: Missing a wheel?},
  author={Antony F Mcdonagh},
  journal={Free radical biology & medicine},
  year={2010},
  volume={49 5},
  pages={814-20}
}
Bilirubin reportedly protects cultured cells from the toxicity of a 10,000-fold molar excess of H(2)O(2). A bilirubin-biliverdin cycling mechanism has been proposed to explain this remarkable effect whereby bilirubin reacts with oxyradicals specifically generating biliverdin, which is then reduced back to bilirubin by NADPH/biliverdin reductase. Chemical evidence for this mechanism was formation of biliverdin during incubation of bilirubin-albumin with 2,2'-azobis(2-amidinopropane… CONTINUE READING

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