The bilirubin-increasing drug atazanavir improves endothelial function in patients with type 2 diabetes mellitus.

Abstract

OBJECTIVE In type 2 diabetes mellitus (T2DM), oxidative stress gives rise to endothelial dysfunction. Bilirubin, a powerful endogenous antioxidant, significantly attenuates endothelial dysfunction in preclinical experiments. The Gilbert syndrome is accompanied by a mild and lifelong hyperbilirubinemia and associated with only one third of the usual… (More)
DOI: 10.1161/ATVBAHA.110.211789

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