The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons.

@article{Castro2004TheBA,
  title={The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons.},
  author={Rui E Castro and Susana Sol{\'a} and Rita Cruz Coelho de Mira Ramalho and Clifford J. Steer and Cec{\'i}lia M. P. Rodrigues},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={311 2},
  pages={845-52}
}
Neurotoxicity associated with increased glutamate release results in cell death through both necrotic and apoptotic processes. In addition, tauroursodeoxycholic acid (TUDCA), an endogenous bile acid, is a strong modulator of apoptosis in several cell types. The aims of this study were to test the hypothesis that TUDCA reduces the apoptotic threshold induced by glutamate in rat cortical neurons and examine potential transduction pathways involved in both apoptotic signaling and neuroprotection… CONTINUE READING