The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain.

@article{Keitel2010TheBA,
  title={The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain.},
  author={Verena Keitel and Boris G{\"o}rg and Hans J{\"u}rgen Bidmon and Irina Zemtsova and L. Art Spomer and Karl Zilles and Dieter H{\"a}ussinger},
  journal={Glia},
  year={2010},
  volume={58 15},
  pages={1794-805}
}
TGR5 (Gpbar-1) is a membrane-bound bile acid receptor in the gastrointestinal tract and immune cells with pleiotropic actions. As shown in the present study, TGR5 is also expressed in astrocytes and neurons. Here, TGR5 may act as a neurosteroid receptor, which is activated by nanomolar concentrations of 5β-pregnan-3α-ol-20-one and micromolar concentrations of 5β-pregnan-3α-17α-21-triol-20-one and 5α-pregnan-3α-ol-20-one (allopregnanolone). TGR5 stimulation in astrocytes and neurons is coupled… CONTINUE READING

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