The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis.

@article{Zamboni2006TheBI,
  title={The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis.},
  author={Paolo Zamboni},
  journal={Journal of the Royal Society of Medicine},
  year={2006},
  volume={99 11},
  pages={589-93}
}
  • Paolo Zamboni
  • Published 2006 in Journal of the Royal Society of Medicine
Impaired venous drainage of the lower extremities, mainly due to venous reflux or to venous outflow obstruction, leads to a cascade of pathological events clinically graded by the clinical class (C) of the CEAP classification (Clinical, aEtiological, Anatomical, Pathophysiological) of chronic venous disease (CVD).1 Varicose veins are the most frequent clinical sign in class C2. When oedema complicates varicose veins, the clinical picture is graded as C3. Pigmentation, lipodermatosclerosis and… CONTINUE READING
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