The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication.

@article{Pakshir2018TheBF,
  title={The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication.},
  author={Pardis Pakshir and Boris Hinz},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2018},
  volume={68-69},
  pages={
          81-93
        }
}
Scarring is part of the normal healing response to tissue injury in all organs and required to rapidly repair acute damages, mostly with extracellular matrix. A variety of different cells are activated into myofibroblasts to produce and remodel the scar matrix. Temporal and spatial coordination of myofibroblast activities with inflammatory macrophages is crucial for the controlled healing process. Miscommunication can result in either insufficient (chronic) or exacerbated (fibrotic) repair. In… CONTINUE READING
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