The bidirectional phase-shifting effects of melatonin on the arginine vasopressin secretion rhythm in rat suprachiasmatic nuclei in vitro.

@article{Svobodov2003TheBP,
  title={The bidirectional phase-shifting effects of melatonin on the arginine vasopressin secretion rhythm in rat suprachiasmatic nuclei in vitro.},
  author={Irena Svobodov{\'a} and Jir{\'i} Vanecek and Hana Zemkova},
  journal={Brain research. Molecular brain research},
  year={2003},
  volume={116 1-2},
  pages={
          80-5
        }
}
In vivo melatonin serves as a feedback signal to the circadian pacemaker located in the suprachiasmatic nuclei (SCN) and in vitro it phase advances the circadian rhythm of electrical activity in pacemaker cells. However, the occurrence and nature of phase shifting in secretion by cultured SCN neurons has not yet been established. Here we studied the effects of melatonin on the pattern of spontaneous arginine vasopressin (AVP) release in organotypic SCN slices. This culture mimicked the in vivo… CONTINUE READING

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