The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

@article{Driever1988TheBP,
  title={The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner},
  author={Wolfgang Driever and Christiane N{\"u}sslein-Volhard},
  journal={Cell},
  year={1988},
  volume={54},
  pages={95-104}
}
The bicoid (bcd) protein in a Drosophila embryo is derived from an anteriorly localized mRNA and comes to be distributed in an exponential concentration gradient along the anteroposterior axis. [...] Key Method To determine whether the levels of bcd protein are directly related to certain cell fates, we manipulated the density and distribution of bcd mRNA by genetic means, measured the resultant alterations in height and shape of the bcd protein gradient, and correlated the gradient with the fate map of the…Expand

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  • 2009
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The maternal gene bicoid organizes anterior development in Drosophila and its mRNA is localized at the anterior tip of the oocyte and early embryo, distributed in an exponential concentration gradient, reaching background levels in the posterior third of the embryo.
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