The beta1a subunit regulates the functional properties of adult frog and mouse L-type Ca2+ channels of skeletal muscle.


The beta(1a) subunit, one of the auxiliary subunits of Ca(V)1.1 channels, was expressed in COS-1 cells, purified by electroelution and electrodialysis techniques and identified by Western blot using monoclonal antibodies. The purified beta(1a) subunit strongly interacted in vitro with the alpha interaction domain (AID) of Ca(V)1.1 channels. The actions of… (More)