The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.

@article{Chang2005TheBK,
  title={The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.},
  author={Qiulian Chang and Susan Hoefs and Annemiete W van der Kemp and Catalin N. Topala and Ren{\'e} J M Bindels and Joost G. J. Hoenderop},
  journal={Science},
  year={2005},
  volume={310 5747},
  pages={
          490-3
        }
}
  • Qiulian Chang, Susan Hoefs, +3 authors Joost G. J. Hoenderop
  • Published in Science 2005
  • Chemistry, Medicine
  • Blood calcium concentration is maintained within a narrow range despite large variations in dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has been implicated in this process. We report here that TRPV5 is stimulated by the mammalian hormone klotho. Klotho, a beta-glucuronidase, hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane. This maintains durable calcium channel activity and membrane calcium permeability in… CONTINUE READING

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