The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.

Abstract

Blood calcium concentration is maintained within a narrow range despite large variations in dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has been implicated in this process. We report here that TRPV5 is stimulated by the mammalian hormone klotho. Klotho, a beta-glucuronidase, hydrolyzes extracellular sugar residues on… (More)

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Cite this paper

@article{Chang2005TheBK, title={The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.}, author={Quanzhong Chang and Sarah H{\"{o}fs and Annemiete W C M van der Kemp and Catalin N. Topala and Ren{\'e} J M Bindels and Joost G. J. Hoenderop}, journal={Science}, year={2005}, volume={310 5747}, pages={490-3} }