The beta -globin recombinational hotspot reduces the effects of strong selection around HbC, a recently arisen mutation providing resistance to malaria.

@article{Wood2005TheB,
  title={The beta -globin recombinational hotspot reduces the effects of strong selection around HbC, a recently arisen mutation providing resistance to malaria.},
  author={Elizabeth T Wood and Daryn A. Stover and Montgomery Slatkin and Michael W Nachman and Michael F. Hammer},
  journal={American journal of human genetics},
  year={2005},
  volume={77 4},
  pages={637-42}
}
Recombination is expected to reduce the effect of selection on the extent of linkage disequilibrium (LD), but the impact that recombinational hotspots have on sites linked to selected mutations has not been investigated. We empirically determine chromosomal linkage phase for 5.2 kb spanning the beta -globin gene and hotspot. We estimate that the HbC mutation, which is positively selected because of malaria, originated <5,000 years ago and that selection coefficients are 0.04-0.09. Despite… CONTINUE READING

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